Officials say the driver of a Honda Pilot was heading northbound in the southbound lanes of the expressway.
Just after 2:15 a.m. Thursday, the driver of the Pilot collided with a southbound Honda HR-V near College Point Boulevard, authorities said.
The driver of the HR-V, a 45-year-old, was pronounced dead at scene. Officials say a 25-year-old man who was in the Pilot was also killed.
They were identified as Joseph Pulido, 25, and Francisco Cureno, 45.
A 35-year-old female passenger in the Pilot is in critical condition at New York-Presbyterian Queens, and a 26-year-old man who was also in the Pilot is at the same hospital in stable condition.
NewsCopter 7 was over the scene as crews worked to clear the roadway. The Whitestone Expressway was closed following the accident.
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