It happened near Farmers Boulevard at 10:45 p.m. Sunday.
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Police say the white BMW sedan was traveling east on the parkway when the driver lost control and slammed into a divider.
A 16-year-old passenger was ejected from the car and died. He was later identified as Ronish Kush.
Another passenger, a young man in his late teens, was taken to Jamaica Medical Center, where medics pronounced him dead.
He was later identified as 18-year-old Sukhmani Singh.
The 19-year-old driver is hospitalized in stable condition.
All three occupants of the crashed vehicle were friends but are not believed to be related.
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The eastbound lanes of the parkway were shut down east of 150th Street for more than six hours as police worked to determine what caused the driver to lose control.
Speed is believed to have been a factor in the crash, but the driver was not intoxicated.
No arrests have been made and the investigation is ongoing.
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