The fire broke out around 1 p.m. Sunday at a home on 96th Street in Flushing.
Flames could be seen shooting through a top-floor window.
A woman at the home told firefighters her son was trapped upstairs.
That's where the 57-year-old man was discovered. He was taken to Elmhurst Hospital where he later died.
The cause of the fire is under investigation.
----------
* More Queens news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube