It happened just before 5 a.m.on I-80 in Roxbury and snarled traffic in the area during the morning commute.
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The trailer was torn in half, with part of it dangling over the side of the bridge.
It's not clear what caused the accident, and there has been no word on any injuries.
Heavy morning traffic built up quickly, as all eastbound lanes were closed, and the delays are expected to last throughout the afternoon and into the evening commute.
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Construction was also going on in the area where the accident happened, and the shoulder was already closed on that part of the roadway.
One eastbound lane reopened by the Friday night rush, but it is unclear how long it would take until the roadway fully reopens.
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