The crash happened at about 3:45 p.m. on Route 172 near the intersection of West Patent Road in Bedford.
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Bedford police said the crash involved a private bus for adults with special needs and another vehicle. Ten ambulances responded to the scene.
The driver of the car, a 55-year-old woman from Stamford, Connecticut, was taken to a nearby hospital with serious injuries.
On the bus, the driver and 11 passengers were all taken to the hospital with non-life threatening injuries. An attendant who was on the bus was not injured.
Route 172 iwasclosed from Interstate 684 to McLain Street in Mt. Kisco while police investigated the crash.
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Police are now working to determine the cause of the crash.
Editor's note: Police initially reported this was a school bus involved, but later updated to say it's a private bus.
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