The crash happened Monday on Palisades Interstate Parkway southbound on the exit 11 ramp in New City, New York.
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New York State Police said one school bus rear-ended the other, and 60 students were taken to Nyack Hospital and Good Samaritan Hospital via ambulances and additional school buses.
The students are from Northern Valley Regional High School in Demarest, New Jersey.
All injures are minor, police said.
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The investigation is ongoing.