The shooting happened just before 9 p.m. at a four-story building on 30th Drive near 23rd Street in Astoria.
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The victims were two women, a man and a young boy about 5 years old, who were all found dead in a first-floor apartment.
Police have not yet released information on the gunman. Investigators say that a weapon has been recovered.
Detectives are investigating whether the deaths may have been a murder-suicide. "We don't lean either way but that is certainly something we will look to," said NYPD Chief of Detectives Dermot Shea.
Police investigate deadly Queens shooting
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The circumstances that led to the shooting are not yet known. It was not immediately clear if the victims were related.
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