Police say it happened at about 1:23 a.m. east of Exit 42 in Bay Shore.
A two-door,1995 Acura Integra left the roadway and struck several trees in the center median, police said.
The driver, 21-year-old Aliem Davis, and the only passenger, 22-year-old Elliot Rodriguez, both of Bay Shore, were pronounced dead at the scene.
New York State Police are asking anyone with information about the crash to call (631) 756-3300.
----------
* More Long Island news
* Send us a news tip
* Download the abc7NY app for breaking news alerts