Police say the deadly discovery was made around 4:30 p.m. at the home on Central Avenue, near Bushwick Avenue, in Bushwick.
Authorities say 46-year-old Otis James was found stabbed several times in the torso, and a knife was found near his body.
He was pronounced dead at the scene.
James was a retired MTA bus driver who was wheelchair bound after he was shot while on vacation in another country.
Police have not released any information about a possible suspect.
"This is tragic news, and our thoughts and prayers are with Mr. James' family," Transit Authority President Andy Byford said in a statement.
James was a bus operator from 2005 until May of 2017, when he retired on disability.
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