It happened shortly before 2 a.m. at the Basics Housing Men's Homeless Shelter on West 83rd Street.
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Police responding to a 911 call found a 36-year-old man on the first floor with a stab wound to the torso and a 22-year-old man on the third floor with stab wounds to the torso.
Both were taken to Mount Sinai St. Luke's Hospital where the 22-year-old was pronounced dead.
The 36-year-old is listed in stable condition and was taken into custody with charges pending.
The stabbing apparently stemmed from a dispute between the two men.
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The investigation is ongoing.
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