The crash was reported in the 5900 block of State Route 82 just before 11 p.m., police said.
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Officials said Tuesday the driver of the vehicle lost control after failing to negotiate a curve on Route 82 and Bulls Head Road.
Driver, 2 passengers killed when car crashes into NY home
The car slammed into a tree in front of the home before the car, the tree and the house all caught fire.
The driver and one of the passengers were pronounced dead at the scene. A passenger in the back seat of the car was taken to the hospital and later pronounced dead.
The identities of the victims have not yet been released.
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The owner of the house was able to escape without injury.
Anyone who may have witnessed the crash is asked to call state police in Poughkeepsie at (845) 677-7379.
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