The fire burned through a row of six attached townhouses located at 909 Patterson Avenue.
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The 4-alarm blaze, which broke out shortly before 4 p.m., started in the rear, outside of the building, which spread rapidly through the entirety of the structure.
About 41 units and 185 firefighter and EMS personnel responded to the scene to contain the fire.
FDNY officials say 11 firefighters suffered minor injuries, some related to heat.
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Authorities advised residents in the area to avoid inhaling smoke by closing their windows and avoiding outdoor activity.
The cause of the fire is under investigation.
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