The fire started around 10 p.m. at a home on Benziger Avenue in New Brighton.
Citizen App video showed flames shooting out of a window of an upper floor.
The two people injured were transported to a local hospital, but their condition is unknown at this time.
The cause of the fire has yet to be determined.
----------
* More Staten Island news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube