Here's the information the DOD has released so far:
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Army Chief Warrant Officer 2 Jonathan R. Farmer was a 37-year-old from Boynton Beach, Florida. He was assigned to the 3rd Battalion, 5th Special Forces Group (Airborne) and was based out of Fort Campbell in Kentucky.
Navy Chief Cryptologic Technician (Interpretive) Shannon M. Kent was a 35-year-old from upstate New York. She was assigned to Cryptologic Warfare Activity 66 based out of Fort George G. Meade in Maryland.
DOD civilian Scott A. Wirtz was from St. Louis, Missouri. He was assigned to the Defense Intelligence Agency as an operations support specialist.
Four Americans were killed and three were injured Wednesday in the blast while conducting a routine patrol - the first instance of U.S. casualties since President Donald Trump announced his intention to withdraw troops from the country last month.
The fourth American who was killed has not yet been identified. The attack was the deadliest assault on U.S. troops in Syria since American forces went into the country in 2015.
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The Islamic State group claimed responsibility for the rare morning attack in the U.S.-patrolled town of Manbij in northern Syria, saying one of its members carried out a suicide attack and detonated his vest filled with explosives.
Videos released by local activists and news agencies showed a restaurant that suffered extensive damage and a street covered with debris and blood. Several cars were also damaged. Another video showed a helicopter flying over the area.
A local town council and a Syrian war monitoring group said the blast occurred near a restaurant near the town's main market, near a patrol of the U.S.-led coalition, killing and wounding more than a dozen people.
The Britain-based Syrian Observatory for Human Rights said 16 people were killed including nine civilians and others were wounded in the blast. It added that at least five U.S.-backed Syrian fighters were also among the dead.
The attack came days after the U.S. began the process of withdrawing from Syria, pulling out equipment from the northeast into neighboring Iraq. Trump abruptly announced his intention to rapidly withdraw the 2,000 troops from Syria just before Christmas, declaring the Islamic State group to be defeated.
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The announcement took some of his closest aides by surprise, upset allies in the region, and led to the resignation of Secretary of Defense Jim Mattis. Since then, U.S. officials and Trump himself have suggested the withdrawal would be slower than initially thought.
The Kurdish Hawar news agency, based in northern Syria, and the Observatory, which monitors the war through activists on the ground, reported U.S. troops were among the casualties.
It was not the first time that forces of the U.S.-led coalition were subjected to attacks in the area, although they have been rare.
In March last year, a roadside bomb killed two coalition personnel, an American and a Briton, and wounded five in Manbij.
The Associated Press and ABC News contributed to this report