The fire started in a store on the first floor of the five-story building located at 404 East 63rd Street.
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Flames shot up a shaft between two buildings and reached the roof.
Eyewitness News was told that three firefighters and one civilian suffered minor injuries.
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Residents living in the building had to be evacuated and will not be allowed to return anytime soon.
It took about 90 minutes to bring the fire under control.
There's no word yet on the cause.
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