It happened around 9 a.m. at Fifth Avenue and East 59th Street, where the MTA says the woman made contact with the right rear of a BxM10 bus.
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Authorities say arriving officers found a 19-year-old woman unconscious and unresponsive with head trauma.
She was pronounced dead at the scene.
The 50-year-old driver of the bus remained at the scene.
The preliminary investigation revealed that both the bicyclist and the bus driver were traveling southbound on Fifth Avenue when they collided.
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The identity of the victim has not yet been released.
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