The crash happened on West 185th Street near near St. Nicholas Ave just before 1:30 p.m.
The teen riding the moped collided with a Jeep traveling eastbound.
He was taken to Harlem Hospital after being thrown from the moped and was pronounced dead.
The driver of the vehicle remained on the scene.
The investigation is ongoing.
This is breaking news. This story will be updated as more information becomes available.
----------
* Get Eyewitness News Delivered
* More Manhattan news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube