The race raises money and awareness for those with developmental disabilities.
There is a 4-mile run, 3K walk, children's races and activities, music and food in the Bandshell at 72nd Street in Central Park.
Eyewitness News anchor Bill Ritter is the emcee and has been for the event since 1999.
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For nearly 60 years, YAI has helped those with autism, Down syndrome and other developmental disabilities, supporting thousands with disabilities and their families.