The incident happened on Wednesday morning at 9:40 in the vicinity of Nepperhan Avenue at Ashburton Avenue.
According to investigators, 22-year-old Joel Thompson of Yonkers got into a dispute at the scene with another young man, and then intentionally drove his vehicle, a 2006 Toyota Corolla, into his girlfriend.
She was pronounced dead at scene.
The victim was identified as 16-year-old Madysen Denman of Yonkers.
Police found the vehicle on Saw Mill River Road and detained the driver; he was taken into custody without incident and the vehicle was impounded as evidence.
Thompson was expected to be arraigned on manslaughter charges on Thursday.