Video posted to social media shows officers trying to forcibly remove demonstrators from the middle of Seventh Avenue.
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Police say numerous arrests were made after some protesters blocked traffic.
The arrests made near 1 Polize Plaza were protesters who had gathered to wait for protesters that had been arrested in Times Square, and were being processed there.
A majority of the arrests were for disorderly conduct.
The protesters called for the abolishment of ICE.
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Earlier in the week, protesters rallied outside 26 Federal Plaza in Lower Manhattan, where property in and around the building was vandalized.
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