Officials say flames broke out in a row of stores below units on Grand Street.
The fire is said to have started in the basement of a deli just after 1:30 a.m., before spreading to other businesses.
Officers were able to safely evacuate all the second-floor residents of the building with no injuries or incidents.
Approximately 40 firefighters responded to the scene.
The building sustained moderate structural damage along with variant degrees of smoke, fire, and water damage throughout the building.
The Red Cross was at the scene to assist residents of the building.
The investigation is ongoing.
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