The event is considered the largest fundraising cycling series in the world.
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Riders could either choose a 30-mile route on Manhattan's west side or a 50-mile route that involves crossing the George Washington Bridge.
Bike MS kicked off at 7 a.m. at Pier 84 on the West Side Highway between 43rd and 44th streets.
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Also on Sunday morning, CaringKind hosted its 34th annual Alzheimer's Walk.
'Caringkind' hosts 34th annual Alzheimer's walk in Central Park
The event began at the Central Park bandshell at 10 a.m.
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The walk raises money to support caregivers of Alzheimer's patients and their families.
WABC-TV's own Mike Marza served as emcee for the event.
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