FDNY officials say the 2-alarm fire started on the third floor on an apartment building on Brighton 13th Street in Brighton Beach just after 9 p.m.
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They say a total of five people were treated and taken to nearby hospitals.
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Approximately 25 units and 106 fire and EMS members were on the scene.
The fire was expected to be placed under control at some point Tuesday night.
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Fire marshals will investigate the cause of the fire.
This is breaking news. This story will be updated as more information becomes available.
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