Gloria Asamoah, 42, was indicted by a grand jury on two counts of murder, as well as other charges on Tuesday.
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Asamoah's 5-year-old twins were found dead in their Mount Hope apartment back on December 18.
Originally, she told police they had recently been sick at school, but an autopsy determined they had been smothered.
Asamoah is being held in a psychiatric ward.
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She will be arraigned on the indictment when she is cleared by doctors.
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