The break-in happened Saturday around 6 p.m. in the area of 59th Street and Ninth Avenue.
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Authorities say the suspects forced their way into the home and a 49-year-old woman inside was raped by one of the suspects.
They ran away after the incident. It is not yet clear if anything was taken from the home.
The suspects are described as males in their 30s, about 5'9" to 6 feet tall, with a medium complexion, slim build, black hair and facial hair.
According to NYPD crime stats, while incidents of rape are down 10% citywide this year compared to last, this neighborhood within the 66th precinct has incidents of rape slightly up -- 22 this year vs 20 last year.
Anyone with information is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782).
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