The incident happened just before 8 p.m. inside 838 Hunts Point Avenue.
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An 81-year-old woman is in critical condition due to carbon monoxide poisoning.
A man was also injured and is listed in stable condition.
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Both victims were transported to Jacobi Hospital.
FDNY officials say elevated carbon monoxide levels were detected.
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FDNY members vented and secured the scene.
An investigation is underway to determine the cause of the leak.
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