It happened just before 2 a.m. on East Loop Road.
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Investigators say the driver was speeding when he lost control, hit a car, then crashed through a guardrail and into the river.
The 42-year-old driver and his father, who was a passenger, managed to get out and swim to shore.
The driver was taken into custody and then transported to Mount Sinai Queens Hospital for treatment.
His father refused medical treatment.
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Police say the driver appeared to be intoxicated.
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