The two-vehicle crash happened just before 5:45 a.m. on East Grand and Spring streets.
Police said a Hyundai Sonata with three people inside appeared to have been fleeing from an earlier incident when the driver ran a red light.
Officials said that caused the collision with the second vehicle -- a taxi with two passengers inside.
The taxi company called Maga said the driver, 47-yera-old Juan Carlos, and a woman inside the car were killed.
Her identity has not yet been released.
Two people from the suspect vehicle were caught after the crash but one passenger ran away.
The investigation is ongoing.
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