FDNY officials say the fire happened just before 3:30 p.m. at a home on 43rd Avenue at 215th Street in Bayside.
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Citizen App video showed flames shooting out of the top floor of the home.
About 25 units and 106 firefighters and EMS personnel responded to the scene.
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It took firefighters around 90 minutes to bring the fire under control.
No injuries were reported.
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The cause of the fire is under investigation.
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