Favorite stars have become like family for loyal viewers, while a new generation of performers ensures the show will remain popular for many years to come.
In the video player above, Eyewitness News Reporter Sandy Kenyon takes a look back at the show's historic run which included a cameo from a familiar-looking face.
Meanwhile, an emotional and heartfelt episode kicked off the show's 60th anniversary Wednesday as the late Sonya Eddy, who played "GH" head nurse Epiphany Johnson was honored and remembered by her cast mates.
MORE: ABC's 'General Hospital' pays tribute to beloved actress Sonya Eddy
ABC's 'General Hospital' pays tribute to beloved actress Sonya Eddy