At around 3:10 a.m., police found the victim with a gunshot wound in his chest, near the Jackie Robinson Houses at 118 East 128 Street.
Two men were allegedly fighting outside when one of them pulled out a gun and shot the victim, who was in his 20's, police said.
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The NYPD is still looking for the gunman, who took off after the incident.
The victim was taken to a local hospital in Harlem where he was pronounced dead.
Law enforcement's investigation is ongoing.
This deadly incident happened just hours after a man was injured in a shooting in the East Village.
The 25-year-old victim was shot in the stomach on St. Mark's Place near Avenue A just after 11 p.m., according to police.
He was taken to a nearby hospital with life-threatening injuries. Police are still searching for the gunman, who fled from the scene of the shooting.
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