The fire happened Tuesday at an apartment building on Edgecombe Avenue around 10 a.m.
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The deputy chief on the scene said the fire started on the 12th floor and spread to the 13th floor and that there was a lot of clutter in the apartment, providing an extra challenge.
The 80-year-old victim was taken to the hospital in critical condition where she later died.
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Two firefighters were also checked out for minor injuries.
The other injuries were not believed to be life-threatening.
Few other details were released.
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