Gunfire erupted outside the Opus Lounge on West 202nd Street just before 4:15 a.m.
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A 35-year-old man was shot in the back and pronounced dead at St Barnabas Hospital.
A 43-year-old man was shot in the right arm and taken to Harlem Hospital in stable condition.
The suspects fled in a white vehicle, and no arrests were immediately made.
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