The man got into a dispute with another man in front of a restaurant on Dyckman Street at around 1:05 a.m. Thursday.
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The dispute escalated, and the man was stabbed. He was pronounced dead at Harlem Hospital.
His girlfriend was not injured.
The suspect took off on bicycle on Dyckman Street.
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Detectives are investigating the motive, including if the victim knew his attacker.
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