The fire started in a two-story building off Randolph Avenue just before 10:30 a.m.
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At one point, firefighters had to leave the building after part of it collapsed.
No firefighters were hurt, but they rescued three people from the building -- two of them, ages 63 and 83, were taken to the hospital in serious condition.
There is no word yet on what sparked the fire.
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The Red Cross is helping residents displaced by the fire.
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