The westbound vehicle jumped the divider and smashed into the Pinelawn Road overpass just before 7 a.m. Wednesday.
The car then caught fire.
One person was taken from the vehicle for treatment at an area hospital.
There was no immediate word on that person's condition.
Earlier crashes in Queens and Lake Success impacted morning traffic on the Long Island Expressway as well.
MORE NEWS | NYC Gridlock Alert 2022: Days to know this holiday season
Gridlock Alert 2022 for NYC
----------
* More Long Island news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube