It happened at around 11 a.m. Saturday at 40th Street and 7th Avenue.
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Police say a man in his 20s was stabbed multiple times by a suspect who fled on foot.
The victim was taken to Bellevue Hospital and treated for injuries not believed to be life-threatening.
He was not cooperating with investigators.
Witnesses described the suspect as a man in his 20s wearing a black jacket, black pants and white sneakers.
He was last seen fleeing south on 7th Avenue and carrying a red bag.
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Anyone with information about the suspect or crime is asked to contact police.
Call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782). You can also submit tips by visiting the CrimeStoppers website at crimestoppers.nypdonline.org or by messaging on Twitter @NYPDTips.
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