The motorcyclist was traveling south on Farmers Boulevard and attempted to turn onto 135th Avenue when it struck a van traveling north, according to police.
The motorcyclist was taken to Jamaica Hospital in critical condition while the driver of the van was uninjured and remained on scene.
There's no criminality suspected at this time, according to police.
Police are looking into whether there were any other occupants aboard the van at the time of the incident.
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