It happened just after 11 p.m. Tuesday in front of a parking garage on West 42nd Street, about half a block from the Port Authority Bus Terminal.
Officers say a man got into an argument with another man, things quickly escalated, and one stabbed the other in the torso.
Eyewitness News is tracking crime and safety across New York City and in your neighborhood
Medics rushed the victim to NYC Health & Hospitals/Bellevue, but he did not survive.
The victim's name has not been released.
The suspect fled the scene. Police have made no arrests.
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