The fire broke out inside a home on Farragut Road in the Flatbush section just after 3:45 a.m.
Three residents were taken to Kings County Hospital.
A 71-year-old man hospitalized in critical condition for smoke inhalation was later pronounced dead.
A 31-year-old woman remains in critical condition and a 65-year-old woman is expected to survive.
A firefighter was taken with minor injuries to Mount Sinai Brooklyn.
Citizen App captured video of the scene.
The cause of the fire is under investigation.
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