The crash happened in the northbound lanes near Lincoln Avenue in Rye Brook just after midnight.
A preliminary investigation by police found that a driver traveling in the wrong direction smashed into another vehicle.
That driver suffered life-threatening injuries. The other victims involved in the crash are being treated for non life-threatening injuries.
Traffic in the crash area resumed around 7 a.m. after being diverted to the Lincoln Avenue exit throughout the night and early commute.
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