Officials said the accident happened before 9:15 p.m. Monday.
Emergency crews on the scene found a half-submerged single motorboat with significant damage near the Harbor One Marine.
According to DEEP officials, the boat hit an east-facing jetty at the mouth of the Connecticut river.
Nine people were on the boat at the time of the crash.
A man was found dead and six people were rushed to the hospital. Two people remained missing into the early morning hours on Tuesday.
The two missing people are not believed to be wearing life jackets.
Rescue workers from Madison, Middletown, West Brook and Deep River also responded to the scene. The Coast Guard and LifeStar used helicopters to assist in the search.
The conditions of those rescued are not yet known.
The cause of the crash is under investigation.
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