It happened around 5:30 p.m. Friday near the intersection of 21st Street and 31st Road in Astoria.
Investigators believe the victims, an 11-year-old boy and a 13-year-old girl, were riding their bicycles when they were struck.
Video from the scene showed damage to a bicycle as well as the front bumper and windshield of a sedan.
Both victims were taken to Harlem Hospital.
There was no word on the extent of their injuries, but both are expected to survive.
The driver stayed at the scene. Charges in the case are pending.
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