The fire started around 5 a.m. on Sunday on the sixth floor of a building on 117th Street and Second Avenue.
Video show firefighters on the scene as flames engulfed and smoke billowed from a window. Officials say the fire was put under control about an hour later.
First responders transported two people with minor injuries to Metropolitan Hospital. One firefighter who was also hurt while battling the flames was taken to another hospital for treatment.
Fire marshals are now trying to determine what caused the fire.
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