The deadly confrontation happened around 6:50 p.m. on Saturday along Beach 13th Street.
According to the NYPD, two men were fighting with a knife but fled the scene before officers arrived.
While canvassing nearby hospitals, police found 33-year-old Nilkinson L. Medina with multiple stab wounds to his chest at St. John's Hospital, where he was later pronounced dead.
Authorities are trying to determine what led up to the attack.
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