Crews responded to the scene on 91st Avenue after police received a 911 call around 7:30 a.m. for a report of a fire inside a detached garage.
Upon arrival, authorities found a man and woman, both unresponsive. First responders subsequently pronounced the victims dead.
More than 60 firefighters responded to the scene, according to the FDNY.
The cause of the fire remains under investigation.
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