It happened just before 8:45 a.m. on Anderson Hill Road in Bernardsville.
Police say the tanker truck carrying 8,000 pounds of gasoline flipped on top of two cars.
Several people were hurt, and police said one person may still be trapped under the truck.
Emergency crews say the tanker was not totally full. so the leakage was minimal.
Police are advising commuters to avoid the area.
The Somerset Hills School District said all schools will remain in session for the entirety of the day Wednesday, but students will remain inside. All athletics and after school activities at Bedwell and BMS will be canceled for the afternoon.
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