Police say the two men got into a dispute outside the shelter on East 97th Street and Third Avenue on the Upper East Side around 4 a.m. Sunday.
The 29-year-old victim suffered a stab wound to the chest.
The 30-year-old suspect is currently on the loose.
Police have not yet released either man's name.
MORE NEWS: NJ man accused of attacking mechanic with bleach at service station
NJ man accused of attacking mechanic with bleach at service station
----------
* Get Eyewitness News Delivered
* More Manhattan news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube
Submit a tip or story idea to Eyewitness News
Have a breaking news tip or an idea for a story we should cover? Send it to Eyewitness News using the form below. If attaching a video or photo, terms of use apply.