Suffolk County Police responded to the scene on Great East Neck Road around 12:30 a.m. on Sunday.
Police say 27-year-old Cristian Banega-Salmendares was driving a Dodge SUV when he lost control and went off the roadway. Officers say the car then struck a low concrete wall before flipping into the air and crashing into the home.
First responders transported Banega-Salmendares along with a married couple who lived in the house to Good Samaritan University Hospital in West Islip for treatment.
Police say their injuries are not considered life-threatening.
Town officials are now assessing the damage to the home.
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