Officers arrested two men at the Courtyard Marriot near Marist College after four shots were fired Sunday morning.
The Poughkeepsie Police Department says both men have gang ties and are known to law enforcement.
They were identified later Monday as 35-year-old Roy Johnson, Jr., and 26-year-old Devin Taylor.
Both men were charged with criminal possession of a weapon and Johnson was also charged with murder.
Authorities say the 53-year-old victim had no connection to the two men. He was visiting for Family Weekend.
During a search of the hotel, authorities say they found a manual for building bombs in one of the rooms as well as materials to make the explosive.
Court records indicate police recovered a 9mm Glock and an AR-style rifle with the serial number removed and "We the People" stamped on it.
Investigators are reviewing surveillance video from the hotel and body camera footage from other responding agencies to piece together the events that led up to the shooting.
Marist College released a statement saying:
"Our deepest condolences go out to the family, and we are offering the full support of the Marist community."
There is no word yet on a motive for the shooting. Multiple agencies in Dutchess County are investigating.
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